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Abidur Rahman Makoto Kobayashi Kotaro Sugimoto Yuta Endo Manabu Kojima Shigenori Furukawa Takafumi Watanabe Shu Soeda Yuko Hashimoto Keiya Fujimori Hideki Chiba 《International journal of molecular sciences》2021,22(7)
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Methods: We generated a monoclonal Ab (mAb) against human/mouse CLDN12 and verified its specificity. By performing immunohistochemical staining and semiquantification, we evaluated the relationship between CLDN12 expression and clinicopathological parameters in tissues from 138 cases of cervical cancer. Results: Western blot and immunohistochemical analyses revealed that the established mAb selectively recognized the CLDN12 protein. Twenty six of the 138 cases (18.8%) showed low CLDN12 expression, and the disease-specific survival (DSS) and recurrence-free survival rates were significantly decreased compared with those in the high CLDN12 expression group. We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively). Conclusions: It can be concluded that a reduced CLDN12 expression predicts a poor outcome for cervical cancer. The novel anti-CLDN12 mAb could be a valuable tool to evaluate the biological relevance of the CLDN12 expression in diverse cancer types and other diseases. 相似文献
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为研究变压器内部故障在线检测方法的有效性及抗干扰性,搭建实际变压器的非线性三维有限元模型.对变压器常见几种类型的内部故障进行详细的结构仿真,通过"场-路耦合法"构建各类型故障的ΔV-I1轨迹.同时,通过对正常绕组的测量信号设置一定的误差,构建了考虑测量误差时的误差轨迹.在此基础上,将正常时的标准轨迹、误差轨迹和各种类型的故障轨迹进行对比分析,通过对ΔV-I1轨迹特征差异的定性分析与定量计算,验证该方法在实际应用中的有效性,总结判断各类型故障的规则,同时针对测量误差所造成的干扰提出了建议. 相似文献
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为研究爆炸冲击波对破片穿孔后板结构的毁伤效应,使用激波管为冲击波加载设备,对不同孔形的预制孔铝板进行冲击波加载.利用三维数字图像相关(3 D-DIC)技术,分析固支预制孔方形铝板在冲击波加载条件下的动态响应,得到预制孔铝板的动态响应和变形失效过程.结合3 D-DIC结果分析孔形对靶板刚度、破坏形式、承载能力的影响.结果表明:圆形孔靶板刚度最大,圆形孔靶板的极限承载能力最大,菱形孔靶板极限承载能力最差;孔形对撕裂破坏的影响主要体现在孔的角点在靶板分布上.该实验结果对固支板结构的抗爆设计具有一定参考价值. 相似文献
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Wenjie Liu Jianmin Liu Shu Xing Xiaobin Li Liwen Han Kechun Liu Tao Wei Mingyang Zhou 《European Journal of Lipid Science and Technology》2021,123(6):2000276
In this study, the anti-atherosclerotic properties of three marine phospholipids (MPLs) extracts from fishery by-products including codfish roe, squid gonad, and shrimp head are verified. Their effects on key factors involved in atherosclerosis are examined and compared to explore whether the differences in their constitutions lead to the differences in the function. All three MPLs dampen oxidation of low- density lipoproteins (LDL) in vitro. Treating RAW264.7 macrophages and HUVECs endothelial cells with each MPLs ranging 10–100 µg mL−1 does not decrease cell viability, yet ox-LDL caused cytotoxicity of both cells are alleviated by 50 or 100 µg mL−1 MPLs treatment. In addition, the three MPLs reduce ox-LDL induced macrophage foam-like transition, mainly through inhibition of lipid uptake. Of the three MPLs, the one from squid gonad exhibits the best effect. On the other hand, all three MPLs modulate inflammatory responses, equally, by inhibiting the adhesion of monocytes to endothelial cells, and decreasing secretion of pro-inflammatory cytokines IL-6 and MCP-1. Using a high-cholesterol diet induced zebrafish model, it is found that all three MPLs, especially the one from squid gonad, alleviates cholesterol accumulation in early plaques, and decreases total cholesterol as well as lipid peroxide in vivo. Practical Applications: As a way of making the best of the increasingly scarce marine resources, valuable lipid components can be recovered from by-products and wastes from the fishery industry. Here, we tested the anti-atherosclerotic effects and the mechanisms of three MPLs extracted from codfish roe, squid gonad, and shrimp head. Our study provides further evidence that marine phospholipids extracted from fishery by-products could protect against atherosclerosis, and helps to elucidate the structure-function relationship of MPLs. 相似文献
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Shi-yuan XU Chu-ming LIU Ying-chun WAN Guang ZENG Yong-hao GAO Shu-nong JIANG 《中国有色金属学会会刊》2021,31(5):1291-1302
The corrosion behaviour of Mg-6Gd-3Y-1Zn-0.3Ag (wt.%) alloy components with different sizes after cooling was investigated. The alloys in the small components (SC) cooled fast, which were composed of α-Mg matrix and coarse long-period stacking ordered (LPSO) phases. The alloys in the large components (LC) cooled slowly, and there were thin lamellar LPSO phases precipitating inside the grains, except for α-Mg matrix and coarse LPSO phases. The hydrogen evolution test revealed that the corrosion rate of LC sample was higher than that of SC sample. Electrochemical impedance spectroscopy (EIS) test showed that the surface film on LC alloys provided worse protection. The corrosion morphologies indicated that the precipitation of the thin lamellar LPSO phases in LC sample caused severe micro-galvanic corrosion, which accelerated the rupture of the surface film. 相似文献
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临兴区块地层非均质性强,具有低孔、低渗、低温、低压的特点,需要后期压裂改造,才能实现工业化气流.随着该区域的钻井数量逐渐增多,储层伤害问题日益突出,笔者对地层进行了敏感性分析,在此基础上,研制了超双疏剂,并对其性能进行了评价.结果表明:超双疏剂能够使岩心孔喉表面润湿性由亲水亲油向疏水疏油转变,有效降低低渗储层发生自吸水锁概率,达到保护储层的目的;同时,3%质量分数的超双疏剂比传统的抑制剂KCl和聚醚胺等具有更好的抑制性能.现场应用表明,加入超双疏剂后的钻井液黏度低、切力高、老化前后性能稳定,应用双疏钻井液体系后现场平均机械钻速提高32.33%,井眼扩大率降低33.89%,作业井日产量平均在35973.5 m3/d. 相似文献
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Naw Rutha PAW Takuma KIMURA Tatsuo ISHIJIMA Yasunori TANAKA Yusuke NAKANO Yoshihiko UESUGI Shiori SUEYASU Shu WATANABE Keitaro NAKAMURA 《等离子体科学和技术》2021,23(10):105505-203
Titanium dioxide (TiO2) nanopowder (P-25;Degussa AG) was treated using dielectric barrier discharge (DBD) in a rotary electrode DBD (RE-DBD) reactor.Its electrical and optical characteristics were investigated during RE-DBD generation.The treated TiO2 nanopowder properties and structures were analyzed using x-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR).After RE-DBD treatment,XRD measurements indicated that the anatase peak theta positions shifted from 25.3° to 25.1°,which can be attributed to the substitution of new functional groups in the TiO2 lattice.The FTIR results show that hydroxyl groups (OH) at 3400 cm-1 increased considerably.The mechanism used to modify the TiO2 nanopowder surface by air DBD treatment was confirmed from optical emission spectrum measurements.Reactive species,such as OH radical,ozone and atomic oxygen can play key roles in hydroxyl formation on the TiO2 nanopowder surface. 相似文献